| Player | Pos | Span | Mat | Start | Sub | YC | RC |
|---|---|---|---|---|---|---|---|
| MM Sagario Cagnani | P | 2006-2019 | 76 | 53 | 23 | 3 | 2 |
| S Arata Perrone | 2016-2019 | 39 | 24 | 15 | 3 | 1 | |
| JC Bado | L | 1992-2010 | 49 | 45 | 4 | 1 | 1 |
| M Belluscio | P | 1985-1995 | 22 | 21 | 1 | 0 | 1 |
| N Brignoni | BR | 1998-2010 | 47 | 38 | 9 | 2 | 1 |
| P Costabile | W | 1989-2003 | 38 | 35 | 3 | 0 | 1 |
| JM Gaminara | F | 2010-2019 | 67 | 63 | 4 | 5 | 1 |
| JJ Gari | 1975-1975 | 4 | 4 | 0 | 0 | 1 | |
| PA Lemoine | P | 1995-2010 | 48 | 41 | 7 | 0 | 1 |
| JR Menchaca | FB,W | 1998-2007 | 39 | 35 | 4 | 1 | 1 |
| M Mendaro | C | 1992-2003 | 47 | 44 | 3 | 0 | 1 |
| AL Ormaechea | 2011-2019 | 45 | 34 | 11 | 2 | 1 | |
| P Pagani | F | 2000-2002 | 8 | 4 | 4 | 0 | 1 |
| A Vilaseca Hontou | 2013-2019 | 55 | 52 | 3 | 1 | 1 |
The count for yellow cards is for single yellows for a player. Two yellow cards in a match are recorded as one red card.
| Records include the following current or recent matches: |
|
Uruguay v Brazil at Montevideo, Aug 30, 2019 [0-0] |
|
Uruguay v Spain at Montevideo, Jun 22, 2019 [21-41 FT] |
|
Uruguay v Argentina XV at Montevideo, Nations Cup, Jun 15, 2019 [28-15 FT] |