| Team | Pts | Pts | Team | HT | HT | Series | Ground | Date | Match | |
|---|---|---|---|---|---|---|---|---|---|---|
| London Irish | 24 | 29 | Harlequins | 6 | 13 | Aviva Premiership | Twickenham | 3 Sep 2011 | Details | |
| Harlequins | 26 | 13 | Northampton | 12 | 7 | Aviva Premiership | The Stoop | 9 Sep 2011 | Details | |
| Harlequins | 42 | 6 | Gloucester | 18 | 6 | Aviva Premiership | The Stoop | 17 Sep 2011 | Details | |
| Worcester | 15 | 17 | Harlequins | 9 | 3 | Aviva Premiership | Worcester | 24 Sep 2011 | Details | |
| Harlequins | 48 | 41 | Sale Sharks | 38 | 17 | Aviva Premiership | The Stoop | 1 Oct 2011 | Details | |
| Leicester | 18 | 27 | Harlequins | 15 | 17 | Aviva Premiership | Leicester | 8 Oct 2011 | Details | |
| Harlequins | 19 | 13 | Exeter | 9 | 0 | Aviva Premiership | The Stoop | 29 Oct 2011 | Details | |
| Bath Rugby | 13 | 26 | Harlequins | 7 | 13 | Aviva Premiership | Bath | 5 Nov 2011 | Details | |
| Harlequins | 39 | 8 | Newcastle | 15 | 5 | Aviva Premiership | The Stoop | 27 Nov 2011 | Details | |
| London Wasps | 16 | 22 | Harlequins | 6 | 7 | Aviva Premiership | Wycombe | 4 Dec 2011 | Details | |
| Harlequins | 11 | 19 | Saracens | 6 | 19 | Aviva Premiership | Twickenham | 27 Dec 2011 | Details | |
| Exeter | 9 | 11 | Harlequins | 6 | 8 | Aviva Premiership | Exeter | 31 Dec 2011 | Details | |
| Northampton | 24 | 3 | Harlequins | 17 | 3 | Aviva Premiership | Northampton | 6 Jan 2012 | Details | |
| Harlequins | 30 | 23 | London Irish | 10 | 13 | Aviva Premiership | The Stoop | 11 Feb 2012 | Details | |
| Harlequins | 16 | 14 | Worcester | 10 | 8 | Aviva Premiership | The Stoop | 18 Feb 2012 | Details | |
| Gloucester | 29 | 23 | Harlequins | 21 | 13 | Aviva Premiership | Gloucester | 25 Feb 2012 | Details | |
| Newcastle | 9 | 9 | Harlequins | 3 | 3 | Aviva Premiership | Newcastle | 2 Mar 2012 | Details | |
| Harlequins | 14 | 6 | Bath Rugby | 3 | 6 | Aviva Premiership | The Stoop | 24 Mar 2012 | Details | |
| Saracens | 19 | 24 | Harlequins | 12 | 14 | Aviva Premiership | Wembley | 31 Mar 2012 | Details | |
| Harlequins | 33 | 17 | London Wasps | 16 | 10 | Aviva Premiership | The Stoop | 14 Apr 2012 | Details | |
| Harlequins | 33 | 43 | Leicester | 26 | 23 | Aviva Premiership | The Stoop | 21 Apr 2012 | Details | |
| Sale Sharks | 10 | 24 | Harlequins | 3 | 15 | Aviva Premiership | Stockport | 5 May 2012 | Details | |
| Harlequins | 25 | 23 | Northampton | 9 | 12 | Aviva Premiership | The Stoop | 12 May 2012 | Details | |
| Harlequins | 30 | 23 | Leicester | 14 | 13 | Aviva Premiership | Twickenham | 26 May 2012 | Details |
| Records include the following current or recent matches: |
|
Harlequins v Leicester Tigers at Twickenham, Aviva Premiership Final, May 26, 2012 [30-23 FT] |
|
Harlequins v Northampton Saints at The Stoop, Aviva Premiership Semi final, May 12, 2012 [25-23 FT] |
|
Harlequins v Leicester Tigers at The Stoop, Aviva Premiership, Apr 21, 2012 [33-43 FT] |
